葡萄糖调节蛋白94在内质网应激诱导肝细胞凋亡中的调控机制研究进展

doi:10.11843/j.issn.0366-6964.2019.10.002

Abstract

Abstract: Intracellular endoplasmic reticulum stress (ERS) is ubiquitous in the widespread stress response of livestock, poultry and human beings. Unfolded protein response caused by chronic ERS triggers apoptotic signaling pathways. Glucose-regulated protein 94 (GRP94) is a marker protein of ERS, which is essential for the regulation of apoptosis via endoplasmic reticulum signaling. This paper reviews the regulation mechanism of GRP94 and its interaction proteins on hepatocyte apoptosis induced by endoplasmic reticulum stress, and how GRP94 plays a role in liver disease, which will provide a scientific reference for the control on the ERS-inducing production conditions in livestock and the treatment of ERS apoptosis-related liver diseases in clinical medicine.

CLC Number:

S813

XIN Hairui, HAO Yue, ZHANG Chuang, GU Xianhong. Research Advance in the Regulation Mechanism of Glucose-regulated Protein 94 in Hepatocyte Apoptosis Induced by Endoplasmic Reticulum Stress[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(10): 1963-1971.

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Research Advance in the Regulation Mechanism of Glucose-regulated Protein 94 in Hepatocyte Apoptosis Induced by Endoplasmic Reticulum Stress

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